ADC Payloads
ADC Cytotoxins
ADC payloads are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a payload. The payload is the most important component as it determines the potency to kill cancer cells of an ADC.
There are many payloads which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors.
ADC Payloads Isoform Specific Products
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ADC Payloads
(217)
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Auristatin
(15)
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Calicheamicins
(1)
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Camptothecins
(42)
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Daunorubicins/Doxorubicins
(11)
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Duocarmycins
(18)
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Maytansinoids
(9)
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Pyrrolobenzodiazepines
(8)
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Traditional Cytotoxic Agents
(24)
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All Product Categories
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ADC Payloads Related Products (370)
Related Products (370)
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Antibodies (2)
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Related Compound Screening Libraries (1)
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ADC Payloads Isoform Comparison
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Auristatin E
0 ImagesAuristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids.
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Dexamethasone (Standard)
0 ImagesSynonyms: Hexadecadrol(Standard); Prednisolone F (Standard)Dexamethasone (Standard) is the analytical standard of Dexamethasone. This product is intended for research and analytical applications. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
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7-MAD-MDCPT
0 Images7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
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NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
![NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride](https://file.medchemexpress.com/product_pic/hy-148819a.gif "Click to View NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Product Detail")
0 ImagesCat. No.: HY-148819APurity: 98.46%NH2-bicyclopentane-7-MAD-MDCPT hydrochloride (Formula I) is a topoisomerase I (TOP1) inhibitor. NH2-bicyclopentane-7-MAD-MDCPT hydrochloride is applicable to the synthesis of the ADC ABBV-969. NH2-bicyclopentane-7-MAD-MDCPT hydrochloride is used in research on lung adenocarcinoma and melanoma.
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Thailanstatin A
0 ImagesThailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.
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Cyclopropaneacetamide-Exatecan
0 ImagesCyclopropaneacetamide-Exatecan is an Exatecan (HY-13631) analogue and an ADC Cytotoxin. Cyclopropaneacetamide-Exatecan can be used to synthesize ADC molecules for cancer research.
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MYX1715
0 ImagesSynonyms: IMP1320MYX1715 is an inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 with IC50 values of 44 nM and 9 nM. MYX1715 exhibits antitumor efficacy against neuroblastoma and gastric cancer in mouse models. MYX1715 can be used as ADC toxin.
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Auristatin F
0 ImagesAuristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .
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NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
![NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT](https://file.medchemexpress.com/product_pic/hy-148819.gif "Click to View NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Product Detail")
0 ImagesNH2-bicyclopentane-7-MAD-MDCPT (Formula I) is a topoisomerase I (TOP1) inhibitor. NH2-bicyclopentane-7-MAD-MDCPT is applicable to the synthesis of the ADC ABBV-969. NH2-bicyclopentane-7-MAD-MDCPT is used in research on lung adenocarcinoma and melanoma.
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SGD-1882
0 ImagesCat. No.: HY-101127CAS No.: 1222490-34-7Synonyms: PBD dimerSGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
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Piericidin A
0 ImagesPiericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity.
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SN-38-d3
0 ImagesSynonyms: NK012-d3SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
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Ansamitocin P-3
0 ImagesSynonyms: Antibiotic C 15003P3; Maytansinol isobutyrateAnsamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.
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10-Acetyl docetaxel
0 ImagesSynonyms: PNU-10138310-Acetyl docetaxel (PNU-101383) is an analog of Docetaxel (HY-B0011), with anticancer activity. 10-Acetyl docetaxel is a microtubule disassembly inhibitor, with antimitotic activity.
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(αR)-Cyclopropaneacetamide-Exatecan
0 ImagesSynonyms: SHR169265(αR)-Cyclopropaneacetamide-Exatecan (SHR169265) is a DNA Topoisomerase I inhibitor with enhanced membrane permeability (with an IC50 of 1.34 μM against the human DNA Topoisomerase I). (αR)-Cyclopropaneacetamide-Exatecan exerts cytotoxic effects by inhibiting the enzymatic activity of Topoisomerase I, and this anticancer effect is independent of the expression level of HER2. (αR)-Cyclopropaneacetamide-Exatecan is an ADC Cytotoxin derived from Exatecan (HY-13631), which can be used in research related to advanced cancers such as breast cancer, gastric cancer, colorectal cancer and non-small cell lung cancer.
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MMAF-OMe
0 ImagesSynonyms: Monomethyl auristatin F methyl esterMMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.
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Glucocorticoid receptor agonist-1
0 ImagesCat. No.: HY-131974CAS No.: 2166375-82-0Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC50 of 2.8 nM extracted from patent WO2017210471A1, compound 41.
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NMT-IN-7
0 ImagesNMT-IN-7 is a N-myristoyl transferase (NMT) inhibitor, with IC50s of 2.1 nM for HsNMT1M, 0.6 nM for SU-DHL-10 cell. NMT-IN-7 can be used as a ADC cytotoxin.
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SN-38 (Standard)
0 ImagesSynonyms: 7-Ethyl-10-hydroxycamptothecin (Standard)SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254).
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PF-06380101
0 ImagesSynonyms: Aur0101; Auristatin-0101PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101 (Aur0101) shows excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs.
